Quanda Nature Reserve contains three vegetation communities which are poorly conserved, Mallee and Red Box Open Woodland, Mallee Shrubland with Spinifex and Open Box Woodland. It also conserves one threatened plant species, and ten threatened fauna species including the endangered kultarr and the vulnerable superb parrot. A large number of Aboriginal sites are present on the reserve, including scarred trees.
The New South Wales National Parks and Wildlife Act 1974 requires that a plan of management be prepared for each nature reserve.
