Willandra National Park is representative of the grassland and cottonbush plains of central western NSW and contains a sample of the Riverine Plain of the Murray Darling Basin Lowlands. The park provides habitat for sixteen threatened animal species and two threatened plant species, including ducks and other waterbirds that use Willandra Creek and the ephemeral lakes within the park.
The park contains a range of Aboriginal sites. In the past Willandra Creek served as an important travel route and source of food for the Ngiyampaa Wangaaypuwan people.